Pentobarbital will minimize the level or effect of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar. pentobarbital will reduce the level or result of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib can be a sensitive CYP3A4 substrate. Coadministration with strong or moderate CYP3A4 inducer... https://ernier179ntr2.prublogger.com/profile