Chemotherapy was potentiated by E7449 and one agent experienced significant antitumor exercise in BRCA-deficient xenografts. Additionally, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, most likely as a result of TNKS inhibition. According to this risk, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and substantially altered expression https://felixpvadh.blognody.com/29413336/5-essential-elements-for-chir-090